Lefaucheur JP, Valeyrie‐Allanore L, Tin SNW, et al. - A single‐center cohort of patients with SJS/TEN was assessed for the persistence of pain. In the study, 81 patients with SJS/TEN were interviewed more than 1 year after the initial episode and were included. Among these patients, 29 patients (36%) were painful suggesting that persistence of chronic pain after SJS/TEN is a common phenomenon. Observations revealed chronic pain syndrome in correlation with a more severe initial acute phase of the disease (larger extent of detachment, higher SCORTEN, elevated rate of admission in ICU and complications, and longer hospital stay). Sensory descriptors are observed to be consistent with sensitization of both small‐diameter nerve fibres (burning and itching sensations) and large‐diameter nerve fibres (mechanical allodynia), however, there was large predominance of the affective‐emotional components of pain. Per findings, complex mechanisms result in persistent pain as long‐term sequela of SJS/TEN, among which mechanisms, psychological factors related to post‐traumatic stress disorder are likely to have a key role.