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Acute toxicities and prognosis of elderly patients with nasopharyngeal carcinoma after intensity-modulated radiotherapy: Prediction with nomogram

Cancer Management and Research Sep 26, 2020

Liang Y, Chen K, Yang J, et al. - In this investigation invoving 214 elderly patients, researchers sought to analyze acute toxicities and prognosis of elderly nasopharyngeal carcinoma (NPC) patients after intensity-modulated radiotherapy and to identify predictors regarding age, chemotherapy, comorbidities, nutrition status, and psychological condition, as well as to establish a nomogram for the prediction of prognosis. Elderly NPC patients were classified into three categories (age of 60– 65, age of 66– 70, and age over 70) and analyzed retrospectively. Data reported that the 3-year, 5-year progress-free survival (PFS) and overall survival, respectively, were 77.9%, 66.3%, 79.3% and 66.8%. Findings revealed that age, ALB level, and T stage were critical for PFS, but chemotherapy or comorbidities were not. Elderly NPC patients had poor prognosis. The easy-to-use nomogram is optimistic to help clinical decision-making.

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