Gao PF, Lin JY, Wang S, et al. - Via the study, researchers examined the antinociceptive efficacy of adjuvant magnesium sulphate to decrease intraoperative and postoperative opioids requirements and their related side effects during hysteroscopy. Seventy patients scheduled for hysteroscopy were randomly assigned to receive intravenous magnesium sulfate 50 mg/kg in 100 ml of isotonic saline over 15 min before anesthesia induction and then 15 mg/kg per hour by continuous intravenous infusion or to receive an equal volume of isotonic saline as placebo. Anesthesia was provided to all patients under a BIS guided monitored anesthesia care with propofol and fentanyl. Outcomes suggest adjuvant magnesium administration as beneficial to decrease intraoperative fentanyl requirement and postoperative pain in hysteroscopy, without cardiovascular side effects. They emphasize assessing and correcting magnesium level in surgical patients with risk factors for hypomagnesemia.