Parisi GF, Cannata E, Manti S, et al. - In the early stages of some lung diseases, the Lung Clearance Index (LCI) has been characterized as being more sensitive than spirometry, so researchers assessed this index in a cohort of patients with a history of childhood cancer for the first time. They assessed 57 off‐treatment childhood cancer survivors (CSs) aged 0 to 18 years old and 50 healthy controls. The multiple breath washout method was used to study LCI and spirometry. In ventilation homogeneity or lung function, CSs did not display any variations from the controls. There was a significant correlation between LCI and the number of years since the last chemotherapy. The findings indicate that patients maintain both good values of respiratory function and good homogeneity of ventilation during childhood. In addition, as LCI increases and worsens as the years pass after the end of the treatment, the tendency toward pulmonary fibrosis, typical of adult CSs, could be identified at an earlier time than spirometry.