Hu Y, Zhang X, Ma Y, et al. - Researchers conducted the study for analyzing the influence of type 2 diabetes mellitus (T2D) duration on cancer incidence. The prospective cancer occurrence was followed by 113,429 women in the Nurses’ Health Study (NHS, 1978-2014) and 45,604 men in the Health Professionals Follow-up Study (HPFS, 1988-2014) who were free of diabetes and cancer at baseline. In the multivariable-adjusted model, incident T2D was linked to a higher risk of cancers in the colorectum, lung, pancreas, esophagus, liver, thyroid, breast, and endometrium. The authors discovered that the pooled hazard ratios ranged from 1.21 for colorectal cancer to 3.39 for liver cancer. Findings suggested an association of incident T2D with higher cancer risk which peaked at nearly 8 years after a diabetes diagnosis. Similar duration-dependent pattern for plasma C-peptide has been observed. The findings support hyperinsulinemia's role in the development of cancer.