Liu L, Wang H, Li Z, et al. - A retrospective cohort was conducted to ascertain if intracytoplasmic sperm injection (ICSI) is correlated with improved outcomes in comparison with conventional in vitro fertilization (IVF) for patients with nonsevere male factor infertility. Between January 2012 and December 2016, couples who received their first-cycle embryo transfer without severe oligoasthenozoospermia (OA) were enrolled in this study. Researchers conducted six subgroup analyses according to the proposed indications for the use of ICSI as follows: non−male factor infertility, advanced maternal age (≥ 38 years), unexplained infertility, low oocyte yield (≤ 6), mild OA, and moderate OA. The data implied that, for all causes of infertility, routine use of ICSI did not result in better pregnancy and perinatal outcomes compared with conventional IVF in the first cycle. The data recognized that ICSI might be correlated with a lower risk of neonatal intensive care unit admission when used in couples with moderate OA. Large prospective studies are needed to confirm the current findings.