Du Y, Sidorenkov G, Heuvelmans MA, et al. - In a high-risk population, researchers assessed how cost-effective lung cancer screening with low-dose computed tomography (LDCT) is. An adapted microsimulation model was utilized in a Dutch cohort of heavy smokers for a lifetime horizon from a health insurance perspective. For women, the optimal screening strategy is biennial screening from the age of 50 to 80 years, with a incremental cost-effectiveness ratio of 21.1 k€/life year gained vs no screening, while for men it was annual screening from 55 to 80 years for men incremental cost-effectiveness ratio 27.6 k€/life year gained vs no screening. In a high-risk population, lung cancer LDCT screening was found to be cost-effective, and the best screening scenario is dependent on gender.