Anderson LJ, Lee J, Mallen MC, et al. - As there are no currently approved treatments for cancer cachexia, researchers sought to assess a number of functional performance measures and verify if they correlate with body composition, energy expenditure, biomarkers, and patient-reported quality of life (QOL). For this cross-sectional study, they compared men with solid tumors with cachexia (CAC; N = 48), vs cachexia (CNC; N = 48), vs weight-stable patients without cancer (CON; N = 37) on physical function, body composition, energy expenditure, cytokines, testosterone, and patient-reported QOL. According to results, patients with CAC had lower total lean and appendicular lean mass, stair climb power, upper body strength, and bioavailable testosterone; they also had higher energy expenditure than CNC or CON. Reduced handgrip, respiratory quotient, and appetite, and higher cytokines and fatigue was seen in CAC vs CON. Findings suggested that, n patients with cancer cachexia, stair climbing power and upper body strength may be differential measurements for functional disability.