Mazidi M, et al. - This study is done among participants from NHANES (2005 to 2012), to investigate major nutrient patterns in US adults as well as to determine their correlation with general and central obesity. This analysis involved 24,182 eligible people; 8,155 with general obesity and 11,730 with central obesity. Experts found three nutrient patterns explaining 50.8% of the variance in dietary nutrients intake. Across quarters of the first nutrient patterns (mostly representative of saturated/mono‐unsaturated fatty acids), a rise in the odds of all types of obesity was noted such that the fourth quarter vs the first quarter was identified to be related to odds ratio of 1.31 (95%CI : 1.13‐1.51) and 1.47 (95%CI : 1.30‐1.66) for general and central obesity, respectively. Lower odds of general or central obesity were reported in correlation with the second nutrient patterns (mostly representative of micro nutrients and vitamins). Overall, findings are indicative of the likely deleterious or protective impacts of nutrient patterns on the risk of general and central obesity, with implication for food‐based strategies to avert and control obesity.