Morlacco A, Mancini M, Soligo M, et al. - In order to ascertain the importance of the endoscopic evaluation in clinically suspected cases of bladder pain syndrome/interstitial cystitis (BPS/IC), using the European Society for the Study of Interstitial Cystitis criteria, researchers assessed 52 individuals [women:92%; median age at evaluation: 45 (32.9-58.2) years] who underwent endoscopic evaluation for clinical suspicion of BPS/IC. At hydrodistension, positive and negative findings were reported in 21 (42%) and 29 (58%) patients, respectively. Eighteen patients were identified to have grade 2-3 glomerulations, while there were Hunner lesions only in 1 patient. At biopsy, 24 pts (51.1%) had positive results, while 23 (48.9%) had negative results. Overall, the positive and negative concordance of 78% was observed between hydrodistension and biopsy results. Findings support the role of cystoscopy with hydrodistension and biopsy in the diagnostic pathway of BPS/IC. However, they emphasize considering the results in the clinical context of the individual patient.