Chen YM, et al. - In view of growing evidence indicating the effectiveness of exercise in easing neuropathic pain, and an increase in the number of publications related to exercise and neuropathic pain over time, researchers sought to present a systematic overview of global scientific research related to exercise and neuropathic pain from 2005 to 2019. Publications on Science Citation Index – Expanded of Web of Science from 2005 to 2019 yielded a total of 676 papers for inclusion in accordance to the adopted criteria. The main focuses of the subject categories of the 676 papers were neuroscience (29.88%), clinical neurology (18.79%) and rehabilitation (10.06%) in Web of Science. When consideration was provided to contribution to scientific research on exercise and neuropathic pain, the United States led the first echelon and had the largest numbers of published papers, citations and H-index. These findings provide useful insight concerning research trends and frontiers, cooperators and cooperative institutions.