Shim YS, et al. - This study was undertaken to evaluate whether and how electrocortical activities are associated with the neuropsychiatric symptoms (NPSs) of Alzheimer’s disease (AD) applying frequency-domain electroencephalography (EEG) spectral source analysis, and the potential electrocortical indices identified. Researchers collected scalp EEG data from 51 patients with AD to evaluate the presence of four NPS subdomains, hyperactivity, psychosis, affective symptoms, and apathy. They collected scalp EEG data from 51 individuals with AD to evaluate the presence of four NPS subdomains, hyperactivity, psychosis, affective symptoms, and apathy. They compared EEG power spectra and the standardized low-resolution brain electromagnetic tomography (sLORETA)-localized EEG cortical sources between the groups with and without the four NPS subdomains in eight frequency bands: 1–4, 4–8, 8–10, 10–12, 12–18, 18–20, 20–30, and 30–45 Hz. The outcomes of this research exhibited that both classical EEG spectral and EEG source analysis could differentiate individuals with and without NPSs, particularly psychosis, and apathy subdomains. It was shown that in patients with NPSs, Spectral, and sLORETA analyses served information helpful for better characterization.