Yang F, Wei Y, Han D, et al. - This study was attempted to evaluate whether and how fibroblasts and macrophages played key roles in the development of hepatocellular carcinoma (HCC). It was shown that in cancer-associated fibroblasts, endosialin is mainly expressed (CAF) in HCC, and its expression inversely associates with patient prognosis. This study's findings demonstrate that endosialin-positive CAF promotes HCC progression and indicate IgG78 as a promising therapeutic candidate for HCC treatment.