Hermosillo-de-la-Torre AE, González-Forteza C, Rivera-Heredia ME, et al. - Given a rise in suicide rates in Mexico and the report that the rates have more than doubled in the state of Aguascalientes during the previous 10 years, as well as considering that few investigations have been able to control for family, neighborhood, and occupational environment factors that may confound the link between psychosocial features and suicidal behavior, researchers analyzed suicidal behavior in adolescents as well as young adults in Mexico using epidemiologic research strategies in order to overcome previous research deficiencies. They performed a case-control study including youth and adults 14–42 years of age. Cases included severe suicidal behavior. Controls were those who had never had a suicidal attempt. Good to excellent precision and accuracy were shown by all measures. Perception of life events as more stressful as well as the presence of worse depression and familial relationships; poorer development of affective, religious, and social resources; higher levels of hopelessness and impulsive behavior; and lower self-esteem, all were noted in cases vs their matched controls. In multivariate analysis, it was evident that a more clear differentiation between cases and controls was enabled by highly probable MDE combined with low self-esteem and the use of two or more drugs in the past month, and thus, suicidal attempt in adolescents and young adults in Aguascalientes, Mexico, may be best predicted by these.