Vu CN, Lewis CM, Bailard NS, et al. - Researchers examined if and how the administration of oral celecoxib, gabapentin, and/or tramadol hydrochloride before surgery affects perioperative opioid requirements in patients undergoing head and neck surgery with free flap reconstruction. They conducted a retrospective case-control study including 357 patients (18 years or older) who were scheduled for head and neck surgery with free flap reconstruction. Of these patients, 149 patients (mean [SD] age, 60.3 [13.7] years; 104 [69.8%] men) received oral celecoxib, gabapentin, and/or tramadol hydrochloride before surgery, and 208 patients (mean [SD] age, 64.2 [13.6] years; 146 [70.2%] men) did not receive any of these medications. Per outcomes, patients who received the medications had reduced opioid use and the duration of stay in the postanesthesia care unit. They indicate a possibility of reduction in opioid use during the perioperative period and shortening of the duration of stay in the postanesthesia care unit in correlation with using a multimodal analgesia regimen, such as celecoxib, gabapentin, and/or tramadol.