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Liver injury due to oral anticoagulants: A population based retrospective cohort study

Liver International Jun 12, 2020

Bjornsson HK, et al. - This study was undertaken to investigate the frequency of drug‐induced liver injury (DILI) due to oral anticoagulants (OACs) in a population based setting. Researchers carried out to search a computerized database in The National Prescription Database distinguishing all patients in Iceland that were prescribed OACs (rivaroxaban, apixaban, dabigatran, edoxaban or warfarin) in 2008‐2017. They conducted a medical chart review in all cases where onset of liver injury followed intake of OACs. They excluded patients with other specific causes of liver injury. They undertaken causality evaluation with the RUCAM method in cases with suspected DILI. During the 10 year study period, rivaroxaban was the only OAC correlated with DILI. It was shown that approximately 1 in 1100 patients treated with rivaroxaban developed DILI. In this population based study, other OACs were not correlated with liver injury.

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