Tamura N, Fujiwara Y, Hashimoto T, et al. - This study was intended to assess FRα expression applying a tissue microarray (TMA) constructed from surgical specimens of lung adenocarcinoma (LADC) and compared with clinicopathological features including the EGFR mutation status and the expressions of PD-L1, PD-L2, PD-1, CD4, CD8, CD204, and αSMA. Researchers tested a total of 466 TMA cores created from 233 LADC patients : FRα-positive expression (FRα-pos)/negative (FRα-neg), 222/11; FRα high expression (FRα-HE)/low (FRα-LE), 190/43. It was shown that tumor FRα expression was significantly higher in LADCs with EGFR mutation than in those with wild-type EGFR. This research findings implied that FRα expression was associated with cancer and microenvironment-immunity markers such as PD-L1 expression, CD8 cells, and αSMA.