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Pulmonary peripheral glandular papilloma and mixed squamous cell and glandular papilloma frequently harbour the BRAF V600E mutation

Histopathology May 15, 2020

Lin DL, Xing XM, Ran WW, et al. - The present study was sought to evaluate the underlying genetic association between glandular papilloma (GP)/mixed squamous cell and glandular papilloma (MP) and ciliated muconodular papillary tumour (CMPT)/bronchiolar adenoma (BA). A clinicopathological review and next‐generation sequencing study of two GPs and five MPs were conducted. This study's findings demonstrate that histologically, GPs/MPs exhibited similar cellular and architectural features to CMPTs/BAs, such as bilayered epithelium, bronchiole‐associated lesions and skipping (discontinuous) growth pattern. Evidence showed that overlapping morphological features and comparable mutation profiles support that peripheral GPs/MPs and CMPTs/BAs are on the same disease spectrum. In the CMPT/BA family, they advocate expanding the concept of CMPT/BA and including GP and MP.

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