Keihani S, Wright LN, Alder NJ, et al. - A retrospective review was performed to analyze the role of baseline gonadotropins in predicting the biochemical response to clomiphene citrate (CC) treatment. Between 2013 and 2018, researchers carried out a retrospective review to obtain data from hypogonadal men treated with CC in two high-volume fertility centers. This study recruited a sum of 332 men with mean ± standard deviation age of 36.2±8.2 years. The data showed that in most men, CC treatment results in significant increases in testosterone levels. This study's findings demonstrate that baseline gonadotropins are not strong prognosticator for treatment response to CC. It was noted that adequate biochemical response with CC trial can be expected in most patients with normal or slightly increased baseline gonadotropin levels.