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A multi‐institutional review of outcomes in biopsy‐proven chronic invasive fungal sinusitis

International Forum of Allergy & Rhinology Apr 17, 2020

Humphreys IM, Wandell GM, Miller C, et al. - Researchers reviewed pathology records for biopsy‐proven chronic invasive fungal sinusitis (CIFS; a rare, life‐threatening infection of the nose and sinuses) from 3 tertiary academic institutions from 1995 to 2016 in order to determine factors that influence survival in 1 of the largest cohorts to date. They assessed 38 patients in this study. The most common underlying diseases were hematologic malignancy and diabetes (32% each). The most common fungus was Aspergillus (63%). At 1, 6, and 12 months, overall survival was 89%, 68%, and 48%, respectively. Worse survival was observed in correlation with absolute neutrophil count (ANC) < 1000 at time of diagnosis and recent chemotherapy (within 1 month of diagnosis). Whereas improved survival was observed at 12 months in correlation with a rising ANC > 1000.

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