Jernigan JA, Hatfield, KM., et al. - Researchers assessed multidrug-resistant bacterial infections in US hospitalized patients, between 2012 and 2017. Researchers applied data from patients hospitalized in a cohort of 890 U.S. hospitals during the period 2012–2017 to generate national case counts for both hospital-onset and community-onset infections caused by methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococcus (VRE), extended-spectrum cephalosporin resistance in Enterobacteriaceae suggestive of extended-spectrum beta-lactamase (ESBL) production, carbapenem-resistant Enterobacteriaceae, carbapenem-resistant acinetobacter species, and MDR Pseudomonas aeruginosa. In this study, 292 cultures per 1000 patient-days was the overall rate of clinical cultures and was stable throughout the time period. In this US, health care–associated antimicrobial resistance places a substantial burden on patients. Future study is required to distinguish improved interventions for both the inpatient and outpatient settings.