• Profile
Close

A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke

Lipids in Health and Disease Apr 07, 2020

Wang Y, et al. - Experts aspired to explore if single nucleotide polymorphisms (SNPs) in promoter of metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) were correlated with the susceptibility to ischemic stroke (IS). The sample consisted of 316 IS patients and 320 age-, gender-, and ethnicity-matched controls. By using a custom-by-design 48-Plex SNPscan kit, four polymorphisms in the promoter of MALAT1 (i.e., rs600231, rs1194338, rs4102217, and rs591291) were genotyped. According to results, the rs1194338 C > A variant in the promoter of MALAT1 was linked to the risk of IS. The haplotype analysis demonstrated that rs600231-rs1194338-rs4102217-rs591291 (A-C-G-C) had a 1.3-fold increased risk of IS. Some independent impact factors for IS including rs1194338 AC/AA, TC, TG, HDL-C, LDL-C, Apo-A1, Apo-B and NEFA were identified by logistic regression analysis. Such findings indicate that the rs1194338 AC/AA genotypes can be a protective factor for IS.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free.
  • 55 lakhs+ doctors trust M3 globally

  • Nonloggedininfinity icon
    Unlimited access to original articles by experts
  • Nonloggedinlock icon
    Secure: we never sell your data
  • Signing up takes less than 2 mins
Try M3 India / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay