Liao J, et al. - This study was seeks to evaluate whether overexpression of CXCR5 in CD4+ T cells of systemic lupus erythematosus (SLE) patients caused by excessive SETD3. In SLE patients, the levels of H3K4me3 and H3K36me3 in CXCR5 promoter were significantly higher than those in healthy controls. Compared with the healthy controls, study reveals that the expression of SETD3 was upregulated in SLE CD4+ T cells. The outcomes of this study display that SETD3 plays a major role in the regulation of CXCR5 expression and the progression of SLE.