Coronavirus disease 19 infection does not result in acute kidney injury: An analysis of 116 hospitalized patients from Wuhan, China
American Journal of Nephrology Apr 03, 2020
Wang L, Li X, Chen H, et al. - Researchers studied clinical data of 116 hospitalized coronavirus disease 19 (COVID-19)-confirmed patients to determine how severe acute respiratory syndrome (SARS)-CoV-2 infection influences renal function in these patients. Mild rise in blood urea nitrogen or creatinine (<26 μmol/L within 48 h) was detected in 12 (10.8%) patients, and trace or 1+ albuminuria in 8 (7.2%) patients among 111 COVID-19-verified patients without chronic kidney disease (CKD). The diagnostic criteria of acute kidney injury (AKI) were not met by all these patients. Additionally, 5 patients suffering from CKD who received regular continuous renal replacement therapy (CRRT) prior to admission were confirmed infection of SARS-CoV-2 and diagnosed as COVID-19. For these 5 patients suffering from CKD, CRRT was given 3 times weekly during hospitalization in addition to therapy for COVID-19. Stable state reflected by renal function indicators was obvious in all 5 patients with CKD, in the course of therapy, with no exacerbation of CKD, and a slow absorption of pulmonary inflammation. All 5 patients with CKD were survived. Overall, in COVID-19, the occurrence of AKI was uncommon. In COVID-19 patients, SARS-CoV-2 infection did not lead to AKI, or aggravate CKD.
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