Cameli P, Gonnelli S, Bargagli E, et al. - By analyzing retrospectively recruited 212 chronic sarcoidosis patients (mean age 56.07 ± 12 years; 97 males), researchers determined the clinical significance of calcium metabolism changes in these patients, with a special emphasis on links with specific disease phenotypes and chitotriosidase (CTO) expression. They detected hypercalciuria in 18.8% of patients, and hypercalcemia in 1.8% of patients. The highest levels of urinary calcium were identified in patients experiencing worsening persistent disease. An inverse correlation with urinary calcium was displayed by diffusing capacity of the lung for carbon monoxide (D_LCO) percentage. In this study, a significant percentage of patients of sarcoidosis had calcium metabolism change, especially hypercalciuria. A correlation of urinary calcium with clinical status, D_LCO, and serum CTO activity was evident, indicating that urinary calcium has a potential role as a biomarker of the activity as well as severity of sarcoidosis.