Jiang X, Ding C, Wang C, et al. - Via reviewing relevant case-control trials, researchers investigated the correlation of paraoxonase 1 (PON1) gene polymorphisms (–108C/T, 55L/M, 192Q/R) and polycystic ovarian syndrome (PCOS) susceptibility. PubMed, Cochrane, Embase, CNKI, VANFUN, and VIP yielded 13 case-control studies for inclusion with 3,660 total patients in the PCOS group and 2,835 in the control group. Outcomes of this meta-analysis suggest association of 192Q/R locus R with higher PCOS susceptibility in both the Asian and Caucasian population. Heterozygote model suggested lower PCOS susceptibility in the population with –108C/T locus T; regressive model revealed higher PCOS susceptibility in the Caucasian population with –108C/T locus T. Higher PCOS susceptibility by regressive model was revealed for the population with 55L/M locus M; dominant model and heterozygote model indicated lower PCOS susceptibility in the Asian population with 55L/M locus M.