Amutha A, Praveen PA, Hockett CW, et al. - Using diabetes registries from two countries—U.S. SEARCH for Diabetes in Youth (SEARCH) and Indian Registry of youth onset diabetes in India (YDR), treatment regimens and glycosylated hemoglobin (A1c) levels were compared in Type 1 (T1D) and Type 2 diabetes (T2D). They identified 4,003 T1D (SEARCH = 1899; YDR = 2104) and 611 T2D (SEARCH = 384; YDR = 227) youth. Higher mean A1c was reported in YDR vs SEARCH (T1D:11.0% ± 2.9% vs 7.8% ± 1.7%; T2D:9.9% ± 2.8% vs 7.2% ± 2.1%). Among T1D youth in SEARCH, a basal/bolus regimen was provided to 65.1%, whereas in YDR, once/twice daily insulin regimen was provided to 52.8%. In SEARCH and YDR, 16.2% vs 1.5% of youth with T1D, respectively, were using pumps. In SEARCH and YDR, a majority of T2D youth were on metformin only (43.0% vs 30.0%), followed by insulin + any oral hypoglycemic agents (26.3% vs 13.7%) and insulin only (12.8% vs 18.9%), respectively. These findings suggest that SEARCH differs from YDR significantly in treatment patterns in T1D and T2D. YDR vs SEARCH youth had higher A1c levels, for both T1D and T2D, regardless of the regimens used. They emphasize the urgent necessity for efforts to achieve better glycemic control for youth to decrease the risk of long‐term complications.