Decline in hepatitis C virus (HCV) incidence in men who have sex with men living with human immunodeficiency virus: Progress to HCV microelimination in the United Kingdom?
Clinical Infectious Diseases Mar 30, 2020
Garvey LJ, Cooke GS, Smith C, et al. - Trends in hepatitis C virus (HCV) incidence in the pre- and post- direct-acting antiviral (DAA) eras were investigated for men who have sex with men (MSM) living with HIV in London and Brighton, United Kingdom. Via performing a retrospective cohort study at 5 HIV clinics in London and Brighton between 2013 and 2018, researchers assessed a total of 378 acute HCV infections, comprising 292 first infections and 86 reinfections. In 2015, peak in the incidence rates of acute HCV in MSM living with HIV was observed at 14.57/1,000 person-years of follow-up. The incidence of first HCV episode had 78% reduction and overall HCV incidence showed a 68% reduction since the epidemic peak in 2015, which coincides with wider access to DAAs in England. For microelimination to be achieved in this population, they suggest the necessity for further interventions to reduce transmission, including earlier access to treatment and for reinfection.
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