Lazo-Porras M, Bernabe-Ortiz A, Ruiz-Alejos A, et al. - Researchers performed the CRONICAS Cohort Study in four distinct areas in Peru, to estimate the prevalence of prediabetes by different definitions, assess regression to normal glucose levels as well as progression towards T2D, and to explore the factors related to regression and progression across four diverse geographical settings in a Latin American country. The definitions from the World Health Organization (WHO), American Diabetes Association (ADA), and National Institute for Health and Care Excellence (NICE) were used. Based on the definition applied, a marked difference was evident in the prevalence of prediabetes at baseline: 6.5%(95% CI 5.6−7.6%), 53.6% (95% CI 51.6−55.6%), and 24.6% (95% CI 22.8−26.4%) by WHO, ADA and NICE criteria, respectively. Much more common finding was regression from pre-diabetes back to euglycemia than progression to diabetes. Age, body mass index, and insulin resistance were identified as the factors that were related to regression to normal glucose levels and progression to diabetes.