Wibulpolprasert P, Raman SS, Hsu W, et al. - This study attempted to investigate the performance of 3-T multiparametric MRI (mpMRI) for prostate cancer (PCa) detection and localization, stratified by anatomic zone and level, utilizing Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) and whole-mount histopathology (WMHP) as reference. Researchers compared multiparametric MRI examinations of 415 consecutive men with thin-section WMHP results. They estimated tumor detection rates for clinical and pathological (tumor location and zone) variables. Both rigid and adjusted sector-matching models were applied to account for fixation-related issues. The detection of overall and index PCa lesions in the mid gland, base, and apex was 54.9% and 83.1%, 42.1% and 64.0%, and 41.9% and 71.4%, respectively, among 863 PCa foci in 16,185 prostate sectors. The study found that, for 3-T mpMRI, the highest sensitivity (83.1%) for the detection of index PCa lesions was in the midgland, with 98.3% specificity. The results suggested that multiparametric MRI performance for sectoral localization of PCa within the prostate was moderate and was best for index lesions in the PZ applying an adjusted model.