Young BE, Ong SWX, Kalimuddin S, et al. - This study intended to describe the initial experience in Singapore with the epidemiologic examination of this outbreak, clinical features, and management. Between January 23 and February 3, 2020, a descriptive case series of the first 18 individuals diagnosed with polymerase chain reaction (PCR)–confirmed SARS-CoV-2 infection at 4 hospitals in Singapore; the final follow-up date was February 25, 2020. Researchers obtained clinical, laboratory, and radiologic data, involving PCR cycle threshold values from nasopharyngeal swabs and viral shedding in blood, urine, and stool. The clinical presentation was an upper respiratory tract infection in 12 (67%), and viral shedding from the nasopharynx was prolonged for 7 days or longer among 15 (83%) among the 18 hospitalized patients with PCR-confirmed SARS-CoV-2 infection (median age, 47 years; 9 [50%] women). The study found that clinical presentation was frequently a mild respiratory tract infection among the first 18 patients diagnosed with SARS-CoV-2 infection in Singapore. In addition, some individuals required supplemental oxygen and had variable clinical results following treatment with an antiretroviral agent.