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Effectiveness of combined behavioral and drug therapy for overactive bladder symptoms in men: A randomized clinical trial

JAMA Internal Medicine Mar 11, 2020

Burgio KL, Kraus SR, Johnson TM, et al. - A randomized clinical trial was designed to ascertain whether combining behavioral and drug therapies improve outcomes correlated with each therapy alone for overactive bladder (OAB) in men and to compare 3 sequences for implementing combined therapy. Individuals were assigned randomly to 6 weeks of behavioral therapy alone, drug therapy alone, or combined therapy followed by step-up to 6 weeks of combined therapy for all groups. Researchers enrolled a total of 204 individuals from 3 outpatient clinics and included community-dwelling men 40 years or older with urinary urgency and 9 or more voids per 24 hours. They obtained data between July 2010 and July 2015 and examined from April 2016 to September 2019. The study found that combining behavioral and drug therapy produces greater improvements in OAB symptoms compared with drug therapy alone but not behavioral therapy alone. When applying a stepped approach, it is reasonable, to begin with, behavioral therapy alone.
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