Anderson C, et al. - Using the Surveillance, Epidemiology, and End Results database, researchers analyzed temporal trends in mortality among five-year adolescent and young adult (AYA) cancer survivors. They selected AYAs (age 15-39) who received a diagnosis of cancer during 1975-2011 and who survived ≥ 5 years beyond diagnosis. A reduction was evident in five-year mortality (ie, from 5 through 10 years post-diagnosis) from all causes, from 8.3% in those diagnosed in 1975-1984 to 5.4% in those diagnosed in 2005-2011, in a sample of 282,969 five-year AYA cancer survivors. Reductions in mortality from primary cancer between these periods largely explained this. However, little improvement in primary cancer-mortality over time was evident in cumulative mortality curves for specific cancer types, such as colorectal, bone, sarcomas, cervical/uterine, and bladder. Reduction in all-cause and cancer-specific mortality has been reported, over the past four decades, among five-year AYA cancer survivors overall, however, many cancer types have not shared in these improvements.