Chao CT, et al. - Since musculoskeletal degeneration is central to frailty development, researchers explored the association between baseline osteoporosis and the subsequent frailty risk in individuals with diabetic kidney disease (DKD). This study included a total of 12,027 individuals having DKD with osteoporosis and 24,054 propensity score-matched controls having DKD but without osteoporosis from the Longitudinal Cohort of Diabetes individuals in Taiwan (n = 840,000). The primary outcome included incident frailty on the basis of a modified FRAIL scale. They applied the Kaplan-Meier technique and Cox proportional hazard regression to examine the relationship between osteoporosis at baseline and incident frailty in these individuals. In individuals with DKD, CKD-related osteoporosis is correlated with a higher risk of incident frailty.