Huddart RA, Hall E, Lewis R, et al. - Researchers examined a total of 458 UK individuals with T2-T4a N0 M0 transitional cell carcinoma of the bladder to ascertain the effect of treatment on the health-related quality of life (HRQoL) of BC2001 individuals. Individuals were assigned randomly to the chemotherapy comparison (radiotherapy, 178, or chemoradiotherapy, 182); and/or to the radiotherapy comparison (standard, 108, or reduced high-dose volume radiotherapy, 111). The results of this study indicated that immediately following (chemo)radiotherapy, a significant proportion of patients report declines in HRQoL, which improves to baseline after 6 months. The study found that two-thirds of individuals report stable or increased HRQoL on long-term follow-up. In HRQoL, there is no indication of impairment occurring from the addition of chemotherapy.