da Silveira SDRB, Auge APF, Jarmy-Dibella ZIK, et al. - This study was undertaken to correlate long-term results in patients who underwent either native tissue repair or monofilament macroporous polypropylene mesh. A multicenter, randomized trial was performed to include—at the end of 5 years follow-up—122 women with severe pelvic organ prolapse, who were randomized to undergo surgical treatment using native tissue repair (native tissue group, n = 59) or synthetic mesh repair (mesh group, n = 63). This study evaluated the quality of life utilizing the prolapse quality-of-life questionnaire and sexual function with the quality of sexual function. Compared with native tissue repair, outcomes in women with severe POP were better with mesh use, both in the anterior compartment and in the multicompartmental prolapse after a 5-year follow-up. It was found that complications were more common in the mesh group and recurrences were more frequent in the native tissue group.