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Prevalence, incidence, and risk of cancer in patients with psoriasis and psoriatic arthritis: A systematic review and meta-analysis

JAMA Feb 26, 2020

Vaengebjerg S, et al. - A Systematic Review and Meta-analysis were performed to assess the evaluation and risk of cancer in individuals with psoriasis or psoriatic arthritis, including the risk of specific cancer subtypes. Researchers screened PubMed and Embase from inception to January 1, 2019, using the search string psoriasis or psoriatic and neoplasms or malignancy or cancer. Cancer (overall and specific subtypes) was the main outcome and prevalence, incidence, and risk estimate were measured for cancer in individuals with psoriasis or psoriatic arthritis. This study included a total of 112 studies involving a sum of 2,053,932 individuals after the assessment of 365 studies. Individuals with psoriasis seem to have a slightly raised risk of cancer, especially keratinocyte cancer and lymphomas. It was demonstrated that the data on treatment with biologic agents did not display an improved risk of cancer. The study's found limited data on cancer in individuals with psoriatic arthritis, and future study is warranted in this area.
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