Halpern JA, Fantus RJ, Chang C, et al. - This study intended to evaluate the correlation between chronic, regular NSAID use and compensated hypogonadism in a large, nationally representative cohort, the US National Health, and Nutrition Examination Survey (NHANES) database. This study included men 20–80 years who answered the analgesic use questionnaire and underwent hormonal testing. They utilized multivariable regression to ascertain the correlation between NSAID use and serum testosterone (T), anti-Mullerian hormone (AMH) and T:AMH ratio. Regular and chronic NSAID use was not correlated with changes in T or compensated hypogonadism in this nationally representative sample of US men. These findings should reassure individuals and clinicians regarding the safety of NSAID use with respect to the risk of alteration in the hypothalamic-pituitary-gonadal axis.