Borojerdi ASD, Welchowski T, Peng W, et al. - The intent of this research was to screen spermatozoa for IL-6R expression and to identify its localization. The researcher examined semen samples of 137 individuals (median age 37.69, SD ± 7.82) with subfertility. Further, sperm analysis including determination of IL-6 was conducted following the World Health Organization criteria. For sperm IL-6R expression, flow cytometry was conducted. The outcomes revealed positive staining for IL-6R in the midpiece of spermatozoa. Moreover, a significant relationship between sperm IL-6R expression, seminal plasma IL-6 and total sperm count could be illustrated, whereas a negative association was seen in sperm IL-6R expression and motility. The results of this study indicated that, during inflammation, IL-6R expression may play a role in impaired sperm function.