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Higher bodily adiposity, fat intake, and cholesterol serum levels are associated with higher disease activity in psoriatic arthritis patients: Is there a link among fat and skin and joint involvement?

Lipids in Health and Disease Feb 13, 2020

Leite BF, Morimoto MA, Gomes C, et al. - This study was sought to assess the association among body composition measurements, food intake, and disease activity in patients with psoriatic arthritis (PsA). Researchers conducted a cross-sectional study including a sum of 97 individuals with PsA, according to the CASPAR criteria. The study investigated body composition measurements (whole-body DXA, GE-Lunar), food intake (3-day registry) and biochemical and inflammatory serum markers. By using PASI, BSA, DAS28, and minimal disease activity (MDA), skin and joint disease activity were evaluated. The data showed a higher prevalence of obesity, according to the fat mass index (FMI) (92.7%), and metabolic syndrome (MetS) (54%), but there were no significant changes regarding lean or bone mass. In patients with PsA, the data imply a possible harmful connection among fat (body adiposity, saturated fat consumption, LDL-cholesterol serum levels) and joint and skin disease activity.
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