Wilson ME, Dobler CC, Morrow AS, et al. - This study was undertaken to investigate the correlation of home noninvasive positive pressure ventilation (NIPPV) via bilevel positive airway pressure (BPAP) devices and noninvasive home mechanical ventilator (HMV) devices with clinical outcomes and adverse events in patients with chronic obstructive pulmonary disease (COPD) and hypercapnia. Between January 1, 1995, and November 6, 2019, researchers searched MEDLINE, EMBASE, SCOPUS, Cochrane Central Registrar of Controlled Trials, Cochrane Database of Systematic Reviews, National Guideline Clearinghouse, and Scopus for English-language articles. The study population consisted of a total of 21 RCTs and 12 observational studies including 51,085 individuals (mean [SD] age, 65.7 [2.1] years; 43% women). Home NIPPV, compared with no device use, was significantly correlated with better clinical results and no significant difference in the quality of life among individuals with COPD and hypercapnia. Nevertheless, the data was low to moderate in quality, the evidence on quality of life was lacking, and the analyses for some outcomes were based on small numbers of studies.