Leslie WD, Schousboe JT, Morin SN, et al. – Researchers designed a registry-based cohort study to assess the correlation between measured height or weight loss on subsequent fracture risk-adjusted for FRAX scores, risk factors, and competing mortality. They distinguished women and men age 40 years or older with height and weight estimated at the time of two dual-energy x-ray absorptiometry (DXA) scans by using a DXA registry for the Province of Manitoba, Canada. A sum of 11,495 individuals (average age 68.0 ± 9.9 years; 94.6% women) were recruited. Cox regression analyses were used to examine for a covariate-adjusted relationship between prior height and weight loss with incident fractures occurring after the second scan applying linked population-based healthcare data. In all, prior height loss was found to be correlated with a small but significant improvement in the risk of incident fracture at all skeletal sites independent of other clinical risk factors and competing mortality as recognized by FRAX. Furthermore, prior weight loss was shown to only increase the risk of subsequent hip fractures.