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Can we clinically distinguish anejaculation from retrograde ejaculation in patients on α1A-blockers therapy for lower urinary tract symptoms

Urology Feb 10, 2020

Pavone C, Abrate A, Li Muli P, et al. - Researchers examined a total of 42 patients in order to find out the physiopathology of ejaculatory disorders (EjD) and discriminate between retrograde ejaculation (REj) and anejaculation (AEj) induced by α1A-blockers, through the relationship between the mean post-orgasm seminal vesicle volume and the appearance of sperm in mid-stream urine, in individuals with moderate-to-severe lower urinary tract symptoms (LUTS) secondary to benign prostatic enlargement. They treated therapy-naïve male individuals with LUTS and without previous EjD with α1A-blockers. Post-orgasm urine was obtained for sperm count and seminal vesicle volume was estimated through transrectal ultrasound after 12 weeks. A relationship was found between the presence of sperm in the mid-stream urine and seminal vesicle volume after orgasm, strongly confirming and differentiating the hypothesis of a dual etiology for EjD (REj vs. AEj) secondary to α1A-blockers therapy for LUTS.
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