Palani A, et al. - This study was conducted to compare geographical differences in semen characteristics between the United States and Iraq. Researchers sought to compare semen parameters of infertile men in the United States (n = 76) that fairly represent the population of a highly developed region and Iraq (n = 102), the representative of male populations of a developing region. According to WHO (WHO laboratory manual for the examination and processing of human semen, WHO; 2010) criteria, samples were obtained and examined by means of the Mann–Whitney test. The US population showed lower sperm concentration, total count, and total and progressive sperm motility with a higher seminal total antioxidant capacity as correlated to the Iraqi population. This report supports further studies concerning the confounding factors leading to such changes in semen qualities between these two geographic areas.