Safety of inadvertent administration of live zoster vaccine to immunosuppressed individuals in a UK-based observational cohort analysis

BMJ Open Feb 03, 2020

Grint1, DJ, et al. – Researchers performed a prospective observational cohort study to evaluate the safety of live attenuated varicella-zoster vaccination when administered to immunosuppressed individuals. This study included 168,767 participants age-eligible for varicella-zoster vaccination who were registered at a general practice in England contributing data to Clinical Practice Research Datalink between 2013 and 2017. Despite data supporting inadvertent vaccination of immunosuppressed individuals with live zoster vaccination, there is a dearth of evidence of severe consequences, including hospitalization. This should assuage primary care staff and encourage vaccination of mildly immunosuppressed individuals who do not meet current thresholds for contraindication.

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