Anderson KB, Buddhari D, Srikiatkhachorn A, et al. - In view of the challenges encountered in the development and evaluation of dengue vaccines due to difficulties inherent in the identification of immune correlates of protection or severe disease and the persistence of substantial gaps in knowledge about the complex effects of age and sequential dengue virus (DENV) exposures on these correlations, researchers undertook this novel family-based cohort-cluster study for DENV transmission in Kamphaeng Phet, Thailand. The study started in 2015 and is funded until at least 2023. Active enrollment of 2,870 individuals in 485 families was made until May 2019. Acute dengue illnesses were identified via active surveillance and subclinical seroconversions were detected via analyzing annual blood draws. In the extended follow-up of this cohort, detection of sequential infections will be done and correlates of antibody kinetics and sequence of infections with disease outcomes will be determined. This prospective study is performed with the central goal of characterizing how various DENV exposure histories within multigenerational family units, from DENV-naïve infants to grandparents with multiple prior DENV exposures, influence transmission, disease, and protection at the level of the individual, household, and community.