Do overactive bladder symptoms and their treatment-associated changes exhibit a normal distribution? Implications for analysis and reporting
Neurourology and Urodynamics Jan 26, 2020
Amiri M, et al. - Experts intended to examine the effectiveness of means vs medians in studies reporting overactive bladder syndrome symptoms and to test for normal distribution of basal values and treatment-associated changes thereof in two large noninterventional studies. They conducted a systematic review of all original studies reporting on at least one overactive bladder syndrome symptom published in four leading urology journals between 2016 and 2017. In this study, 86% reported means (assuming a normal distribution), 6% medians (not making this assumption), and 8% a combination thereof among 48 eligible articles. Dominant recording of means indicates the hypothesis of a normal distribution of overactive bladder syndrome symptoms but the finding from two noninterventional studies do not support this assumption. They suggest that basal values and absolute symptom changes should be notified as medians and subjected to nonparametric analysis; this means may be appropriate for the reporting of percentage fluctuations of symptoms.
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