Nardin M, et al. - Researchers investigated the impact of smoking on the immature platelet fraction (IPF) and its association with the prevalence and extent of coronary artery disease (CAD). They included a cohort of consecutive patients undergoing coronary angiography in a single center. Significant CAD was defined as ≥ 1 vessel stenosis > 50%, while severe CAD was defined as left main and/or three-vessel disease. They assessed IPF at admission by routine blood cell count. All 2,553 study participants were divided into two groups according to smoking status: active smokers (n = 512) and nonactive smokers (n = 2,041). In patients undergoing coronary angiography, researchers found an independent correlation between active smoking and the levels of immature platelet fraction. However, among active smokers, IPF was not found to be an independent predictor of CAD or severe CAD.