Vassallo G, Mughal Z, Robinson L, et al. - Investigators sought to explain the prevalence and severity of perceived fatigue in a young neurofibromatosis type 1 (NF1) population. They obtained ethical approval and invited 286 families NF1 affected people (n = 75) aged 2–18 years along with any unaffected siblings (n = 16) from the Manchester's NF1 clinic. There were notable variations among NF1 and controls in the aggregated fatigue core and the three sub-domains such as cognitive, physical and sleep/rest. Finding suggests that in comparison with healthy children who do not have NF1, children with NF1 were affected by perceived fatigue.