Argaman Y, Kisler LB, Granovsky Y, et al. - In view of the observed relation of altered pain modulation and resting-state functional connectivity (rsFC) with migraine pathology and clinical manifestation, researchers examined the relationship of pain modulation psychophysical measures with resting-state networks and rsFC between bottom-up and top-down pain modulation areas. They performed temporal summation of pain (TSOP) and conditioned pain modulation (CPM) tests, followed by a resting-state imaging scan in 32 episodic migraineurs and 23 age-matched healthy individuals. The groups did not exhibit any difference in TSOP and CPM. However, in healthy individuals, they noted more efficient CPM which was correlated with: 1) stronger rsFCs of the posterior cingulate cortex, with the ventromedial prefrontal cortex and with the pregenual anterior cingulate cortex; 2) weaker rsFC of the anterior insula with the angular gyrus. However, migraineurs exhibited an alteration in the correlation between CPM and rsFC. This work yielded evidence supporting the correlation between the resting-state brain and individual responses in psychophysical pain modulation tests, in both migraine and healthy individuals. Results suggest that the default mode network plays a significant role in maintaining pain inhibition efficiency in health and in the presence of chronic pain.